Surprisingly, stimulating only a few synapses with BDNF transmits more PSD-95 to excitatory synapses through the entire whole neuron within the hour. This recently described pan-neuron effect of local synaptic stimulation is comparable to synaptic tagging, which is a mechanism originally proposed to describe how a few very energetic synapses can prime larger parts of a neuron for long-term synaptic strengthening in response to subsequent stimulation.Costa brings a uncommon combination of scientific knowledge and personal mission to this important function,’ the Alana Foundation said in a statement. ‘His progress to day demonstrates the power of those qualities, and provides us confidence that extra studies will yield a lot more significant results. ‘ This year the foundation made two awards, each of $1.7 million, to Case Western Reserve and MIT. Li-Huei Tsai, PhD, director of MIT's Picower Institute for Learning and Memory and an expert in Alzheimer's disease research, will serve seeing that principal investigator at MIT.