This article was reprinted from kaiserhealthnews.org with permission from the Henry J. Kaiser Family Foundation. Kaiser Health Information, an editorially independent news service, is a scheduled plan of the Kaiser Family members Foundation, a nonpartisan health care policy research corporation unaffiliated with Kaiser Permanente.. CSIS report examines global polio eradication efforts The Center for Strategic & International Research on Monday released a written report called Eradicating Polio in Afghanistan and Pakistan.For instance, cannabinoid antagonists targeting the CB1 receptor, such as brokers being developed to treat obesity, have been associated with such central side effects as negative feeling and depression. Furthermore, cannabinoid agonists targeting CB1 receptors, including applicants being developed for treatment, have demonstrated the potential for abuse. By performing at the periphery instead of in the CNS selectively, the CeNeRx cannabinoid compounds have the prospect of great therapeutic efficacy without these adverse effects. Mr. Brand added, ‘Issuance of the new patent also reinforces the ongoing worth of our collaboration with this discovery partner PharmaNess, who played a central part in identifying the structure-activity relationship of the series and in working key preclinical versions that validated the part of these compounds in a variety of circumstances including glaucoma, pain, spasticity and obesity.