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The prescribing details for Aricept and Aricept RDT has been up to date with this important safety information. Producers of generic donepezil items will update their item information also. In addition, Health Canada has published an overview Safety Review with more details on its review. What you should do: If symptoms of rhabdomyolysis or NMS are noticed, donepezil ought to be stopped instantly and a doctor or a pharmacist ought to be contacted right away. Symptoms of rhabdomyolysis include a combination of fever, muscle tissue or joint discomfort, weakness, nausea, and dark urine. Symptoms of NMS consist of high fever, muscle rigidity or stiffness, mental changes including agitation and delirium, and irregular pulse and heartbeat.